2. Autophagy PROTAC
  3. AUTACs
  4. Halo PROTAC 1

Halo PROTAC 1 is a conjugate of ligands for E3 and 22-atom-length linker. The connector of linker is Halogen group. Halo PROTAC 1 is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker. Halo PROTAC 1 can be uesd for the synthesis of AUTAC.

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Halo PROTAC 1 Chemical Structure

Halo PROTAC 1 Chemical Structure

CAS No. : 2241668-45-9

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1 mg USD 360 In-stock
5 mg USD 900 In-stock
10 mg USD 1450 In-stock
25 mg USD 2900 In-stock
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Based on 1 publication(s) in Google Scholar

Halo PROTAC 1 Related Antibodies

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Description

Halo PROTAC 1 is a conjugate of ligands for E3 and 22-atom-length linker. The connector of linker is Halogen group. Halo PROTAC 1 is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker. Halo PROTAC 1 can be uesd for the synthesis of AUTAC[1].

Molecular Weight

774.76

Formula

C33H49Cl2N7O8S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClCCCCCCOCCOCCOCCOCCOCCNC([C@@H](NC(C)=O)CSC1=NC(C(N=C(N)N2)=O)=C2N1CC3=CC=C(Cl)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (193.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2907 mL 6.4536 mL 12.9072 mL
5 mM 0.2581 mL 1.2907 mL 2.5814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2907 mL 6.4536 mL 12.9072 mL 32.2681 mL
5 mM 0.2581 mL 1.2907 mL 2.5814 mL 6.4536 mL
10 mM 0.1291 mL 0.6454 mL 1.2907 mL 3.2268 mL
15 mM 0.0860 mL 0.4302 mL 0.8605 mL 2.1512 mL
20 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6134 mL
25 mM 0.0516 mL 0.2581 mL 0.5163 mL 1.2907 mL
30 mM 0.0430 mL 0.2151 mL 0.4302 mL 1.0756 mL
40 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8067 mL
50 mM 0.0258 mL 0.1291 mL 0.2581 mL 0.6454 mL
60 mM 0.0215 mL 0.1076 mL 0.2151 mL 0.5378 mL
80 mM 0.0161 mL 0.0807 mL 0.1613 mL 0.4034 mL
100 mM 0.0129 mL 0.0645 mL 0.1291 mL 0.3227 mL
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Halo PROTAC 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halo PROTAC 12241668-45-9Halo PROTAC1Halo PROTAC-1AUTACsAutophagy-targeting chimerasInhibitorinhibitorinhibit

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