2. Anti-infection
  3. Bacterial
  4. Hamamelitannin

Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release.

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Hamamelitannin Chemical Structure

Hamamelitannin Chemical Structure

CAS No. : 469-32-9

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Based on 1 publication(s) in Google Scholar

Hamamelitannin Related Antibodies

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Description

Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release[1][2].

In Vitro

Hamamelitannin displays specific cytotoxic activity against colon cancer cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hamamelitannin Related Antibodies
Molecular Weight

484.36

Formula

C20H20O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.46 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0646 mL 10.3229 mL 20.6458 mL
5 mM 0.4129 mL 2.0646 mL 4.1292 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0646 mL 10.3229 mL 20.6458 mL 51.6145 mL
5 mM 0.4129 mL 2.0646 mL 4.1292 mL 10.3229 mL
10 mM 0.2065 mL 1.0323 mL 2.0646 mL 5.1615 mL
15 mM 0.1376 mL 0.6882 mL 1.3764 mL 3.4410 mL
20 mM 0.1032 mL 0.5161 mL 1.0323 mL 2.5807 mL
25 mM 0.0826 mL 0.4129 mL 0.8258 mL 2.0646 mL
30 mM 0.0688 mL 0.3441 mL 0.6882 mL 1.7205 mL
40 mM 0.0516 mL 0.2581 mL 0.5161 mL 1.2904 mL
50 mM 0.0413 mL 0.2065 mL 0.4129 mL 1.0323 mL
60 mM 0.0344 mL 0.1720 mL 0.3441 mL 0.8602 mL
80 mM 0.0258 mL 0.1290 mL 0.2581 mL 0.6452 mL
100 mM 0.0206 mL 0.1032 mL 0.2065 mL 0.5161 mL
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Hamamelitannin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hamamelitannin469-32-9BacterialinfectionssuppressorTRAPcytotoxiccoloncancercellsquorum-sensingpeptidoglycanantibioticInhibitorinhibitorinhibit

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