Harzianic acid 

Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide^[1][2].

Acetohydroxyacid synthase (AHAS)^[2]

Harzianic acid shows significant antimicrobial activity against MRSP and MSSP, with MIC values of 32 μg/mL and 16 μg/mL, respectively^[1].
Harzianic acid (8-128 μg/mL) exhibits low cytotoxicity on HaCaT cells^[1].
Harzianic acid inhibits fungal ThAHAS as a competitive inhibitor with a Ki of 6.65 μM^[2].
Harzianic acid (0.1-100 μg/mL) inhibits pathogenic fungi growth^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

365.42

C₁₉H₂₇NO₆

157148-06-6

CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445.  [Content Brief]

  [2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988.  [Content Brief]