2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. HBT1

HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons.

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HBT1 Chemical Structure

HBT1 Chemical Structure

CAS No. : 489408-02-8

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Based on 1 publication(s) in Google Scholar

HBT1 Related Antibodies

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Description

HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons[1].

Molecular Weight

386.39

Formula

C16H17F3N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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HBT1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBT1489408-02-8HBT 1HBT-1iGluRIonotropic glutamate receptorsAMPAAMPA-RS518LBDglutamateBDNFprimary neuronsInhibitorinhibitorinhibit

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