HBV-IN-20

Cat. No.: HY-145872: FAQs
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HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).

For research use only. We do not sell to patients.

HBV-IN-20 Chemical Structure

CAS No. : 2750254-34-1

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Description

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators)^[1].

IC₅₀ & Target

EC₅₀: 0.46 µM (HBV)^[1]

In Vitro

HBV-IN-20 (compound 61) (5 µM; 6 days) is a typical type II CpAM (core protein assembly modula tors)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HepDES19 cells
Concentration:	5 µM
Incubation Time:
Result:	Was a typical type II CpAM (core protein assembly modula tors).

In Vivo

HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability^[1].
Pharmacokinetic Parameters of HBV-IN-20 in mouse^[1].

Compd	Admin.	Cl-obs (mL/min/kg)	T_1/2 (hr)	AUC_last (h*ng/mL)	V_ss-obs (L/kg)	C_max (ng/mL)	F (%)
61	i.v.	25.5	0.6	1952	0.8
	p.o.		0.7	4516		2727	69

Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse^[1]
Dosage:
Administration:	3 mg/kg for i.v.; 10 mg/kg for p.o.
Result:	Showed 69% of oral bioavailability.

Molecular Weight

324.78

Formula

C₁₆H₁₈ClFN₂O₂

CAS No.

2750254-34-1

SMILES

ClC(C=C1NC(N2[C@@]3([H])[C@@](CCCC3)([H])C(CC2)=O)=O)=C(C=C1)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hwang N, et al. 4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators. Bioorg Med Chem Lett. 2022; 58:128518. [Content Brief]

HBV-IN-20 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBV-IN-202750254-34-1HBVHepatitis B virusurea derivativesHepDES19 cellsII CpAMADMEToral activemetabolic stabilityInhibitorinhibitorinhibit

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