HBV-IN-23

Cat. No.: HY-146395: FAQs
Data Sheet Handling Instructions

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HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication with an IC₅₀ of 0.58 μM. HBV-IN-23 inhibits HBV DNA replication in both agent sensitive and resistant HBV strains. HBV-IN-23 shows anti-hepatocellular carcinoma cell (HCC) activities. HBV-IN-23 induces HepG2 cells apoptosis.

For research use only. We do not sell to patients.

HBV-IN-23 Chemical Structure

CAS No. : 2413649-89-3

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Description

IC₅₀ & Target

IC₅₀: 0.58 µM (HBV DNA replication)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	5.44 μM Compound: 5k	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 32791397]
HepG2 2.2.15	CC₅₀	> 10 μM Compound: 5k	Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32791397]
Huh-7	IC₅₀	6.42 μM Compound: 5k	Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 32791397]
SK-HEP1	IC₅₀	6.75 μM Compound: 5k	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 32791397]

Molecular Weight

449.57

Formula

C₂₅H₂₇N₃O₃S

CAS No.

2413649-89-3

SMILES

CN(CCCOC1=CC=C2N=C(N(C(C2=C1)=O)CC3=CC=CO3)SCC4=CC=CC=C4)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qiu J, et al. Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents. Eur J Med Chem. 2020 Nov 1;205:112581. [Content Brief]

HBV-IN-23 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBV-IN-232413649-89-3HBVDNA/RNA SynthesisApoptosisHepatitis B virusHepG2HUH7SK- cellsBadBaxanti-HBVanti-HCCInhibitorinhibitorinhibit

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