2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAI/II-IN-1

hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC50 values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively.

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hCAI/II-IN-1 Chemical Structure

hCAI/II-IN-1 Chemical Structure

CAS No. : 2422028-82-6

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hCAI/II-IN-1 Related Antibodies

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC50 values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively[1].

IC50 & Target

IC50: 0.024 µM (hCA II), 0.047 µM (hCA I)[1]
Ki: 0.013 µM (hCA II), 0.032 µM (hCA I)[1]
Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
> 1000 μM
Compound: 3h
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32388113]
Molecular Weight

459.65

Formula

C18H29N5O3S3
CAS No.
SMILES

CN(CCCN1CCN(CC1)C(SCC(NC2=CC=C(C=C2)S(N)(=O)=O)=O)=S)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCAI/II-IN-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAI/II-IN-12422028-82-6Carbonic AnhydraseCarbonate dehydratasesulfonamideNIH/3T3embryonic fibroblast cellInhibitorinhibitorinhibit

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