HCAIX-IN-1

Cat. No.: HY-146206: FAQs
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HCAIX-IN-1 (compound 21e) is a potent and selective HCAIX inhibitor with K_Is of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively.

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HCAIX-IN-1 Chemical Structure

CAS No. : 2389034-65-3

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

HCAIX-IN-1 (compound 21e) is a potent and selective HCAIX inhibitor with K_Is of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively^[1].

IC₅₀ & Target^[1]

hCA I

694.9 nM (Ki)

hCA II

126.6 nM (Ki)

hCA IX

3.3 nM (Ki)

hCA XII

9.8 nM (Ki)

Molecular Weight

403.42

Formula

C₁₆H₁₇N₇O₄S

CAS No.

2389034-65-3

SMILES

COC1=CC=C(C=C1)NC(NC2=NN(C(N)=N2)C3=CC=C(C=C3)S(N)(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Said MA,et al. Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2020 Jan 1;185:111843. [Content Brief]

HCAIX-IN-1 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCAIX-IN-12389034-65-3Carbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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