hCAIX-IN-10

Cat. No.: HY-147827: FAQs
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hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with K_i s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells.

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hCAIX-IN-10 Chemical Structure

CAS No. : 2497504-72-8

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description	hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with K_i s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells^[1].
IC₅₀ & Target	Ki: 61.5 nM (hCA IX), 586.8 nM (hCA XII)^[1]
In Vitro	hCAIX-IN-10 (compound 6i) is a strong inhibitor of hCA IX rather than hCA XII in vitro^[1]. hCAIX-IN-10 (0.1 nM-0.1 mM; 6 h) inhibits carbonic anhydrases enzyme activity^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. hCAIX-IN-10 Related Antibodies
Molecular Weight	479.55
Formula	C₂₈H₂₁N₃O₃S
CAS No.	2497504-72-8
SMILES	O=C1N(C2=CC=CC(C)=C2)C(C3=CN(C4=CC=CC=C4)N=C3C5=CC6=CC=CC=C6OC5=O)SC1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272. [Content Brief]

hCAIX-IN-10 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-102497504-72-8Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrasetransmembranebiomarkertumorInhibitorinhibitorinhibit

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