hCAIX-IN-19

Cat. No.: HY-157135: FAQs
Data Sheet Handling Instructions

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hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (K_I) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117).

For research use only. We do not sell to patients.

hCAIX-IN-19 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (K_I) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117)^[1].

IC₅₀ & Target

hCA IX

6.2 nM (Ki)

In Vitro

hCAIX-IN-19 (1.0-100.0 μM, 48 h ) shows antiproliferative activity in U87MG cells, MDA-MB-231 cells and PANC-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	U87MG cells, MDA-MB-231 cells, PANC-1 cells
Concentration:	1.0 μM, 3.0 μM, 10.0 μM, 30.0 μM, 100.0 μM
Incubation Time:	48 h
Result:	Obviously affected cell proliferation at 100 μM in U87MG cells. Reduced cell proliferation to 39% at the highest dose tested in MDA-MB-231 cells.

Molecular Weight

566.73

Formula

C₂₉H₃₄N₄O₄S₂

SMILES

O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(N(CC3=CC=C(C=CC=C4)C4=C3)CCC5=CC=C(S(=O)(N)=O)C=C5)=O)([H])N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Begines P, et al. Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies [J]. Bioorganic & Medicinal Chemistry, 2023, 94: 117467. [Content Brief]

hCAIX-IN-19 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-19Carbonic AnhydraseCarbonate dehydratasehCAIX-IN-19 (1.0-100.0 μM48h ) shows antiproliferative activity in U87MG cellsMDA-MB-231 cells and PANC-1 cells^[1].Inhibitorinhibitorinhibit

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