hCAIX-IN-8

Cat. No.: HY-147722: FAQs
Data Sheet Handling Instructions

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hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC₅₀s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential.

For research use only. We do not sell to patients.

hCAIX-IN-8 Chemical Structure

CAS No. : 2414633-40-0

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC₅₀: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	11.22 μM Compound: 7i	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32209296]
HT-29	IC₅₀	8.44 μM Compound: 7i	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32209296]

In Vitro

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC₅₀是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively^[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.35

Formula

C₁₉H₁₆N₄O₆

CAS No.

2414633-40-0

SMILES

COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424. [Content Brief]

hCAIX-IN-8 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-82414633-40-0Carbonic AnhydraseCarbonate dehydrataselow toxicityHEK293apoptosisHT29HepG2 cellsmigrationanti-proliferationInhibitorinhibitorinhibit

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