2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX/XII-IN-8

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II.

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hCAIX/XII-IN-8 Chemical Structure

hCAIX/XII-IN-8 Chemical Structure

CAS No. : 59994-64-8

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hCAIX/XII-IN-8 Related Antibodies

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

IC50 & Target

hCA XII

6.7 nM (Ki)

hCA IX

8.5 nM (Ki)

hCA II

72.0 nM (Ki)

hCA I

5269 nM (Ki)

Molecular Weight

426.28

Formula

C16H13Cl2N5O3S
CAS No.
SMILES

O=C(N(N=C/1C)C2=CC=C(Cl)C=C2Cl)C1=N\NC(C=C3)=CC=C3S(=O)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCAIX/XII-IN-8 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX/XII-IN-859994-64-8Carbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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