1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAIX/XII-IN-8

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II.

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hCAIX/XII-IN-8 Chemical Structure

hCAIX/XII-IN-8 Chemical Structure

CAS No. : 59994-64-8

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Description

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

IC50 & Target

hCA XII

6.7 nM (Ki)

hCA IX

8.5 nM (Ki)

hCA II

72.0 nM (Ki)

hCA I

5269 nM (Ki)

Molecular Weight

426.28

Formula

C16H13Cl2N5O3S

CAS No.
SMILES

O=C(N(N=C/1C)C2=CC=C(Cl)C=C2Cl)C1=N\NC(C=C3)=CC=C3S(=O)(N)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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hCAIX/XII-IN-8
Cat. No.:
HY-156181
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