1. Anti-infection
  2. HCV
  3. HCV-IN-39

HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons.

For research use only. We do not sell to patients.

HCV-IN-39 Chemical Structure

HCV-IN-39 Chemical Structure

CAS No. : 2087916-31-0

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Description

HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons[1].

IC50 & Target

EC50: 0.644 μM (GT1a), 0.952 μM (GT1b), 0.154 μM (GT1b CES1)[1]

Cellular Effect
Cell Line Type Value Description References
Huh-7 EC50
0.154 μM
Compound: 18a
Antiviral activity against HCV genotype 1b Con1 over expressing CES1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 over expressing CES1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
[PMID: 31740203]
Huh-7 EC50
0.644 μM
Compound: 18a
Antiviral activity against HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
[PMID: 31740203]
Huh-7 EC50
0.952 μM
Compound: 18a
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
[PMID: 31740203]
Molecular Weight

610.78

Formula

C21H26BrClN3O9P

CAS No.
SMILES

CCOC(C(C)(N[P@](OC[C@H]1O[C@H]([C@](Br)([C@@H]1O)Cl)N2C=CC(NC2=O)=O)(OC3=CC=CC=C3)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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HCV-IN-39 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
HCV-IN-39
Cat. No.:
HY-147763
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