HDAC/HSP90-IN-3

Cat. No.: HY-144694: FAQs
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HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC₅₀ values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.

For research use only. We do not sell to patients.

HDAC/HSP90-IN-3 Chemical Structure

CAS No. : 2700035-54-5

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HSP90

0.83 μM (IC₅₀, fungal Hsp90)

HDAC

0.91 μM (IC₅₀, fungal HDACs)

human HDAC

3.0 μM (IC₅₀, human HDACs)

HSP90

19.52 μM (IC₅₀, human Hsp90)

In Vitro

HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.57

Formula

C₂₆H₃₃N₅O₆

CAS No.

2700035-54-5

SMILES

CC(C1=CC(C2=NNC(N2C3=CC=C(C=C3)C(NCCCCCCCC(NO)=O)=O)=O)=C(C=C1O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li C, Tu J, Han G, Liu N, Sheng C. Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. Eur J Med Chem. 2022 Jan 5;227:113961. [Content Brief]

HDAC/HSP90-IN-3 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC/HSP90-IN-32700035-54-5HSPHDACFungalHeat shock proteinsHistone deacetylaseslow toxicityantifungaldrug resistanceCandida albicanscandidiasisheat shock protein 90 (Hsp90)histone deacetylase (HDAC)invasive fungal infections (IFIs)Inhibitorinhibitorinhibit

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