HDAC/HSP90-IN-4

Cat. No.: HY-146212: FAQs
Data Sheet Handling Instructions

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These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.

For research use only. We do not sell to patients.

HDAC/HSP90-IN-4 Chemical Structure

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
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Description	These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.
Formula	C₂₀H₂₃N₃O₆
SMILES	CC(C1=CC(C(N(C2=CC=C(C=C2)NC(CC(NO)=O)=O)C)=O)=C(C=C1O)O)C.[n].[n=6,7]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Mehndiratta S,et al. N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression. Eur J Med Chem. 2020 Jan 1;185:111725. [Content Brief]

HDAC/HSP90-IN-4 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC/HSP90-IN-4HDACHSPHistone deacetylasesHeat shock proteinsInhibitorinhibitorinhibit

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