2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-46

HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC).

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HDAC-IN-46 Chemical Structure

HDAC-IN-46 Chemical Structure

CAS No. : 2562386-85-8

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HDAC-IN-46 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC)[1].

IC50 & Target[1]

HDAC1

0.21 μM (IC50)

HDAC6

0.021 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
88.46 μM
Compound: 12c
Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
MCF7 IC50
83.34 μM
Compound: 12c
Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
MDA-MB-231 IC50
21.4 μM
Compound: 12c
Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
In Vitro

HDAC-IN-46 (compound 12c) has antiproliferative activity against MDA-MB-231, A549 and MCF-7 with IC50s of 88.46±10.5 μM, 83.34 ± 15.5 μM and 21.4±3.7 μM, respectively[1].
HDAC-IN-46 (5, 12.5 and 25 μM; 24 h) causes concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1 in MDA-MB-231 cells[1].
HDAC-IN-46 (12.5 and 25 μM; 48 h) induces significant G2 phase arrest and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-46 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 5, 12.5 and 25 μM
Incubation Time: 24 h
Result: Caused concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 12.5 and 25 μM
Incubation Time: 48 h
Result: Induced significant G2 phase arrest and apoptosis.
Molecular Weight

438.53

Formula

C22H30N8O2
CAS No.
SMILES

O=C(NO)CCCCCCCN1N=NC(C2=CC=C(C3=C(CC)N=C(N)N=C3N)C=C2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-46 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-462562386-85-8HDACApoptosisHistone deacetylasesanticancerantiproliferativetriple-negative breast cancerTNBCMDA-MB-231A549MCF-7Inhibitorinhibitorinhibit

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