2. Cell Cycle/DNA Damage Autophagy Epigenetics
  3. Autophagy HDAC
  4. HDAC-IN-62

HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain.

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HDAC-IN-62 Chemical Structure

HDAC-IN-62 Chemical Structure

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HDAC-IN-62 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain[1].

IC50 & Target

0.78, 1.0, 1.2? μM for HDAC6/8/11[1]
Molecular Weight

302.35

Formula

C15H14N2O3S
SMILES

O=C(/C=C/C1=CC=C(/C=C/C(NO)=O)N1C)C2=CC=CS2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-62 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-62AutophagyHDACHistone deacetylasesmicroglialanti-inflammatoryanti-depressantnitric oxideInhibitorinhibitorinhibit

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