2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-76

HDAC-IN-76 (compound 6i) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-76 IC50 values of 30 nM and 98 nM for Pf3D7 (chloroquine (HY-17589A) drug-susceptible strain) and PfDd2 (chloroquine (HY-17589A) drug-resistant strain), has a highly potent antimalarial activity against asexual blood-stage Plasmodium, respectively, and exhibits selective inhibition against parasites, with IC50 values of 7 nM and 9 nM for human HDAC1 and HDAC6, respectively, while inhibiting PfHDAC1.

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HDAC-IN-76 Chemical Structure

HDAC-IN-76 Chemical Structure

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HDAC-IN-76 Related Antibodies

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Description

HDAC-IN-76 (compound 6i) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-76 IC50 values of 30 nM and 98 nM for Pf3D7 (chloroquine (HY-17589A) drug-susceptible strain) and PfDd2 (chloroquine (HY-17589A) drug-resistant strain), has a highly potent antimalarial activity against asexual blood-stage Plasmodium, respectively, and exhibits selective inhibition against parasites, with IC50 values of 7 nM and 9 nM for human HDAC1 and HDAC6, respectively, while inhibiting PfHDAC1[1].

IC50 & Target

hHDAC1

7 nM (IC50)

hHDAC6

9 nM (IC50)

In Vitro

HDAC-IN-76 has low toxicity to HEK293 cells[1].
HDAC-IN-76 (1 μM) effectively inhibits PfHDAC1 with an inhibition rate of 70.2%[1].
HDAC-IN-76 has low activity against liver-stage parasites (IC50 PbEEF (Extraerythrocytic liver stage of Plasmodium berghei)=0.25 μM), good microsomal stability (t1/2 > 60 min), and low toxicity in HEK293 cells (IC50=136 μM, selectivity index SI=544)[1].
HDAC-IN-76 can effectively enter HepG2 cells and inhibit HDAC activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-76 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEK293
Concentration: 1%
Incubation Time: 24 h
Result: Had low cytotoxicity to HEK293 cells.
Molecular Weight

470.52

Formula

C27H26N4O4
SMILES

O=C(CN(C(C1=CN(C)C2=C1C=CC=C2)=O)CC3=CC=C(C(NO)=O)C=C3)NCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-76 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-76HDACHistone deacetylasesHistone deacetylaseHDAC inhibitorsHEK293Inhibitorinhibitorinhibit

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HY-161984
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