2. Cell Cycle/DNA Damage Epigenetics Apoptosis Autophagy NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. HDAC Apoptosis Autophagy Reactive Oxygen Species Mitochondrial Metabolism Parasite
  4. HDAC-IN-88

HDAC-IN-88 (Compound HJ-9) is the inhibitor for HDAC that inhibits HDAC6, HDAC1, HDAC2, HDAC8 and HDAC3 with IC50s of 0.226, 1.103, 2.308, 3.255 and 3.864 μM, respectively. HDAC-IN-88 inhibits the proliferation of cancer cell HepG2, HCT116 and MV4-11 with IC50 of 5.47, 9.78 and 0.38 μM, inhibits the migration of HCT116, arrests the cell cycle at G0/G1 phase, and induces apoptosis and autophagy in MV4-11. HDAC-IN-88 reduces ROS level and mitochondrial membrane potential. HDAC-IN-88 exhibits antimalarial activity that inhibits P. falciparum 3D7 with EC50 of 165 nM. HDAC-IN-88 also exhibits anti-angiogenic activity.

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HDAC-IN-88 Chemical Structure

HDAC-IN-88 Chemical Structure

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HDAC-IN-88 Related Antibodies

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Description

HDAC-IN-88 (Compound HJ-9) is the inhibitor for HDAC that inhibits HDAC6, HDAC1, HDAC2, HDAC8 and HDAC3 with IC50s of 0.226, 1.103, 2.308, 3.255 and 3.864 μM, respectively. HDAC-IN-88 inhibits the proliferation of cancer cell HepG2, HCT116 and MV4-11 with IC50 of 5.47, 9.78 and 0.38 μM, inhibits the migration of HCT116, arrests the cell cycle at G0/G1 phase, and induces apoptosis and autophagy in MV4-11. HDAC-IN-88 reduces ROS level and mitochondrial membrane potential. HDAC-IN-88 exhibits antimalarial activity that inhibits P. falciparum 3D7 with EC50 of 165 nM. HDAC-IN-88 also exhibits anti-angiogenic activity[1].

IC50 & Target

HDAC6

0.226 μM (IC50)

HDAC1

1.103 μM (IC50)

HDAC2

2.308 μM (IC50)

HDAC8

3.255 μM (IC50)

HDAC3

3.864 μM (IC50)

Molecular Weight

432.56

Formula

C23H36N4O4
SMILES

O=C(NO)CCCCC1=CN(N=N1)[C@@H]2C([H])[C@]3([H])CC[C@@H](C)[C@@]4([H])[C@]35[C@](C[C@](C)(OO5)CC4)([H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-88 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-88HDACApoptosisAutophagyReactive Oxygen SpeciesMitochondrial MetabolismParasiteHistone deacetylasesPlasmodium falciparumantimalarialHepG2HCT116MV4-11Inhibitorinhibitorinhibit

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