2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC1-IN-8

HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor with IC50 values of 11.94, 22.95, >500 µM for HDAC1, HDAC6, HDAC8, respectively. HDAC1-IN-8 shows antiproliferative activity. HDAC1-IN-8 induces cell cycle arrest at G1 and G2/M. HDAC1-IN-8 induces autophagy. HDAC1-IN-8 shows anticancer activity and has the potential for the research of lung cancer.

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HDAC1-IN-8 Chemical Structure

HDAC1-IN-8 Chemical Structure

CAS No. : 3066143-73-2

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HDAC1-IN-8 Related Antibodies

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Description

HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor with IC50 values of 11.94, 22.95, >500 µM for HDAC1, HDAC6, HDAC8, respectively. HDAC1-IN-8 shows antiproliferative activity. HDAC1-IN-8 induces cell cycle arrest at G1 and G2/M. HDAC1-IN-8 induces autophagy. HDAC1-IN-8 shows anticancer activity and has the potential for the research of lung cancer[1].

IC50 & Target[1]

HDAC1

11.94 μM (IC50)

HDAC6

22.95 μM (IC50)

HDAC8

>500 μM (IC50)

Molecular Weight

380.44

Formula

C22H24N2O4
CAS No.
SMILES

O=C(NO)CCCCCOC1=CC(C=C2)=C(C=C1)N=C2C3=CC=C(OC)C=C3
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Purity & Documentation
References
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HDAC1-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC1-IN-83066143-73-2HDACHistone deacetylasesH1975A549 cellsH1299antiproliferative activitylung cancerautophagyG1G2/ManticancerInhibitorinhibitorinhibit

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