2. Cell Cycle/DNA Damage Epigenetics Stem Cell/Wnt
  3. HDAC YAP
  4. HDAC11-IN-1

HDAC11-IN-1 (Compound 14-NC6OH) is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2.

For research use only. We do not sell to patients.

HDAC11-IN-1 Chemical Structure

HDAC11-IN-1 Chemical Structure

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HDAC11-IN-1 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC11-IN-1 (Compound 14-NC6OH) is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2[1].

IC50 & Target[1]

HDAC11

40 nM (Ki)

Molecular Weight

881.12

Formula

C43H63F3N6O6S2
SMILES

FC(F)(C1=CC=CC=C1C[C@@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CCCCCC(N(CCCCCC)O)=O)C(NCCCSC2)=O)=O)=O)NC(CCSCC3=CC=CC2=N3)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC11-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC11-IN-1HDACYAPHistone deacetylasesYes-associated proteinHEK293TT-47DHelaInhibitorinhibitorinhibit

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