2. Cell Cycle/DNA Damage Epigenetics PI3K/Akt/mTOR
  3. HDAC AMPK
  4. HDAC11-IN-2

HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 ×10-3 μM and 5μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylationof AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver.

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HDAC11-IN-2 Chemical Structure

HDAC11-IN-2 Chemical Structure

CAS No. : 2919766-97-3

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HDAC11-IN-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 ×10-3 μM and 5μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylationof AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1].

IC50 & Target[1]

HDAC11

0.0511 μM (IC50)

HDAC8

5 μM (IC50)

AMPK α1β1γ1

 

Molecular Weight

425.56

Formula

C25H35N3O3
CAS No.
SMILES

CCCCCOCCCCCNNC(C1=CC=C(CNC(C2=CC=CC=C2)=O)C=C1)=O
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HDAC11-IN-2 Related Classifications

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Keywords:

HDAC11-IN-22919766-97-3HDACAMPKHistone deacetylasesAMP-activated protein kinasechronic liver disorderlipid accumulationfatty acid oxidationHepG2 cellsAML12 cellsHEK293T cellsInhibitorinhibitorinhibit

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