1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. HDAC2-IN-2

HDAC2-IN-2 (compound 124) is an inhibitor of HDAC2 with Kd value of 0.1-1 μM.

For research use only. We do not sell to patients.

HDAC2-IN-2 Chemical Structure

HDAC2-IN-2 Chemical Structure

CAS No. : 332169-78-5

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Based on 1 publication(s) in Google Scholar

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Description

HDAC2-IN-2 (compound 124) is an inhibitor of HDAC2 with Kd value of 0.1-1 μM[1].

IC50 & Target

Kd: 0.1-1 μM (HDAC2)[1]

Molecular Weight

353.40

Formula

C18H15N3O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC2=C1C=CC=C2)SCC(C3=CC=C(NC(C)=O)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 23.81 mg/mL (67.37 mM; ultrasonic and adjust pH to 3 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8297 mL 14.1483 mL 28.2965 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8297 mL 14.1483 mL 28.2965 mL 70.7414 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL 14.1483 mL
10 mM 0.2830 mL 1.4148 mL 2.8297 mL 7.0741 mL
15 mM 0.1886 mL 0.9432 mL 1.8864 mL 4.7161 mL
20 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5371 mL
25 mM 0.1132 mL 0.5659 mL 1.1319 mL 2.8297 mL
30 mM 0.0943 mL 0.4716 mL 0.9432 mL 2.3580 mL
40 mM 0.0707 mL 0.3537 mL 0.7074 mL 1.7685 mL
50 mM 0.0566 mL 0.2830 mL 0.5659 mL 1.4148 mL
60 mM 0.0472 mL 0.2358 mL 0.4716 mL 1.1790 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
HDAC2-IN-2
Cat. No.:
HY-164050
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