2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC3-IN-1

HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM.

For research use only. We do not sell to patients.

HDAC3-IN-1 Chemical Structure

HDAC3-IN-1 Chemical Structure

CAS No. : 2044701-99-5

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Customer Review

Based on 1 publication(s) in Google Scholar

HDAC3-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE HDAC3-IN-1

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM[1].

IC50 & Target

HDAC3

5.96 ± 0.0 nM (IC50)

HDAC1

36.4 ± 0.2 nM (IC50)

HDAC2

89.9 ± 0.7 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HL-60 EC50
> 10000 nM
Compound: 3b
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
HL-60 IC50
51.68 nM
Compound: 17
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
[PMID: 34942071]
K562 EC50
2160 nM
Compound: 3b
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
MOLM-13 IC50
102.7 nM
Compound: 17
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
[PMID: 34942071]
MOLM-14 EC50
76.64 nM
Compound: 3b
Cytotoxicity against human MOLM-14 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human MOLM-14 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
MV4-11 IC50
36.37 nM
Compound: 17
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
[PMID: 34942071]
MV4-11 EC50
36.37 nM
Compound: 3b
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
RPMI-8226 EC50
> 10000 nM
Compound: 3b
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
RS4-11 EC50
151.7 nM
Compound: 3b
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
RS4-11 IC50
81.97 nM
Compound: 17
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
[PMID: 34942071]
U-937 IC50
161.4 nM
Compound: 17
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 34942071]
Molecular Weight

337.42

Formula

C20H23N3O2
CAS No.
SMILES

O=C(/C=C/C1=CC=CC=C1)NCC2=CC=C(C=C2)C(NNCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3-IN-12044701-99-5HDACHistone deacetylasesEnzyme inhibitorhistone deacetylasescontinuous assayslow-binding kineticspreincubationInhibitorinhibitorinhibit

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