HDAC6-IN-10

Cat. No.: HY-150595: FAQs
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HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC₅₀ of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells.

For research use only. We do not sell to patients.

HDAC6-IN-10 Chemical Structure

CAS No. : 2408286-73-5

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•Related Small Molecules:

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View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

HDAC6

0.73 nM (IC₅₀)

HDAC10

105 nM (IC₅₀)

HDAC8

513 nM (IC₅₀)

HDAC7

752 nM (IC₅₀)

HDAC11

1800 nM (IC₅₀)

HDAC9

2560 nM (IC₅₀)

HDAC5

4370 nM (IC₅₀)

HDAC4

5620 nM (IC₅₀)

HDAC1

8020 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	IC₅₀	33.183 μM Compound: 21b	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 31865013]
U-266	IC₅₀	43.233 μM Compound: 21b	Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 31865013]

In Vitro

HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6^[1].
HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HCT-116
Concentration:	0.1, 1 and 10 μM
Incubation Time:	24 hours
Result:	Showed a dose-dependent increase in the level of Ac-tubulin.

Cell Proliferation Assay^[1]

Cell Line:	RPMI-8226 and U266 cells
Concentration:	0-100 μM
Incubation Time:	72 hours
Result:	Showed antiproliferative activities against RPMI-8226 and U266 with the IC₅₀s of 33.183 μM and 43.233 μM, respectively.

Molecular Weight

392.41

Formula

C₂₁H₂₀N₄O₄

CAS No.

2408286-73-5

SMILES

O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xin Chen, et al. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. Eur J Med Chem. 2020 Feb 1;187:111950. [Content Brief]

HDAC6-IN-10 Related Classifications

Molarity Calculator
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-102408286-73-5HDACMicrotubule/TubulinHistone deacetylasesHCT-116RPMI-8226U266anti-proliferative activityInhibitorinhibitorinhibit

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