2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. HDAC Microtubule/Tubulin
  4. HDAC6-IN-10

HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells.

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HDAC6-IN-10 Chemical Structure

HDAC6-IN-10 Chemical Structure

CAS No. : 2408286-73-5

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HDAC6-IN-10 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1].

IC50 & Target[1]

HDAC6

0.73 nM (IC50)

HDAC10

105 nM (IC50)

HDAC8

513 nM (IC50)

HDAC7

752 nM (IC50)

HDAC11

1800 nM (IC50)

HDAC9

2560 nM (IC50)

HDAC5

4370 nM (IC50)

HDAC4

5620 nM (IC50)

HDAC1

8020 nM (IC50)

In Vitro

HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6[1].
HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-10 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 hours
Result: Showed a dose-dependent increase in the level of Ac-tubulin.

Cell Proliferation Assay[1]

Cell Line: RPMI-8226 and U266 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed antiproliferative activities against RPMI-8226 and U266 with the IC50s of 33.183 μM and 43.233 μM, respectively.
Molecular Weight

392.41

Formula

C21H20N4O4
CAS No.
SMILES

O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-102408286-73-5HDACMicrotubule/TubulinHistone deacetylasesHCT-116RPMI-8226U266anti-proliferative activityInhibitorinhibitorinhibit

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