HDAC6-IN-27

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HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC₅₀ vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects.

For research use only. We do not sell to patients.

HDAC6-IN-27 Chemical Structure

CAS No. : 2758023-91-3

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Biological Activity
Purity & Documentation
References
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Description

HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC₅₀ vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects^[1].

IC₅₀ & Target^[1]

HDAC6

15.9 nM (IC₅₀)

HDAC8

136.5 nM (IC₅₀)

HDAC6

6180.2 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	22.28 μM Compound: 8c	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33668008]
Jurkat	IC₅₀	8.03 μM Compound: 8c	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33668008]
MCF7	IC₅₀	> 50 μM Compound: 8c	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33668008]
NAMALVA	IC₅₀	4.79 μM Compound: 8c	Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33668008]

Molecular Weight

301.30

Formula

C₁₅H₁₅N₃O₄

CAS No.

2758023-91-3

SMILES

O=C(C1=CC=C(NC(NC2=CC=C(OC)C=C2)=O)C=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maurício T Tavares, et al. 1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors. Sci Rep. 2023 Nov 29;13(1):21006. [Content Brief]

HDAC6-IN-27 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-272758023-91-3HDACParasiteHistone deacetylasesHDAC6antiparasitic effectsInhibitorinhibitorinhibit

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