2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-37

HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue.

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HDAC6-IN-37 Chemical Structure

HDAC6-IN-37 Chemical Structure

CAS No. : 2986486-82-0

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HDAC6-IN-37 Related Antibodies

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Description

HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue[1].

Molecular Weight

385.87

Formula

C19H16ClN3O2S
CAS No.
SMILES

O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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HDAC6-IN-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-372986486-82-0HDACHistone deacetylasesAlzheimer's diseaseHDAC6 inhibitorsInflammationNeurotransmittersOxidative stressInhibitorinhibitorinhibit

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