HDAC8/BRPF1-IN-1

Cat. No.: HY-151366: FAQs
Data Sheet Handling Instructions

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HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC₅₀ of 443 nM against human HDAC8 and a K_d of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6.

For research use only. We do not sell to patients.

HDAC8/BRPF1-IN-1 Chemical Structure

CAS No. : 2484255-85-6

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

hHDAC8

443 nM (IC₅₀)

hBRPF1

67 nM (Ki)

In Vitro

HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Acute myeloid leukemia cells THP-1 and HL60
Concentration:	4, 20 and 100 μM
Incubation Time:	24 h
Result:	Inhibited THP-1 and HL60 cells growth.

Molecular Weight

417.44

Formula

C₁₉H₁₉N₃O₆S

CAS No.

2484255-85-6

SMILES

O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ghazy E, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338. [Content Brief]

HDAC8/BRPF1-IN-1 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8/BRPF1-IN-12484255-85-6HDACEpigenetic Reader DomainHistone deacetylasesBRPF1acute myeloid leukemiaHDAC8Inhibitorinhibitorinhibit

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