HDAC8-IN-4

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HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC₅₀s of 0.15 and 12 μM.

For research use only. We do not sell to patients.

HDAC8-IN-4 Chemical Structure

CAS No. : 1600528-05-9

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Biological Activity
Purity & Documentation
References
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Description

HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC₅₀s of 0.15 and 12 μM^[1].

IC₅₀ & Target^[1]

HDAC8

0.15 μM (IC₅₀)

HDAC3

12 μM (IC₅₀)

In Vitro

HDAC8-IN-4 (Compound 9) (1 to 100 μM, 5-6 days) inhibits HDAC8 protein level in HeLa cells^[1].
HDAC8-IN-4 (0-50 μM approximately, 72 h) inhibits T-cell lymphoma cells (Jurkat, HH, MT4, HUT78 cells) growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Jurkat, HH, MT4, HUT78 cells
Concentration:	0-50 μM approximately
Incubation Time:	72 h
Result:	Inhibited cell growth with IC₅₀s of 2, 7.4, 5.8, 27 μM).

Western Blot Analysis^[1]

Cell Line:	HeLa cells
Concentration:	0-40 μM
Incubation Time:	4 h
Result:	Selectively inhibited HDAC8 over other HDACs in cells.

Molecular Weight

342.44

Formula

C₁₇H₁₄N₂O₂S₂

CAS No.

1600528-05-9

SMILES

O=C(C1=CC=CC(C2=CSC(CSC3=CC=CC=C3)=N2)=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. ChemMedChem. 2014 Mar;9(3):657-64. [Content Brief]

HDAC8-IN-4 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-41600528-05-9HDACHistone deacetylasesT-celllymphomaHeLaJurkatHHMT4HUT78Inhibitorinhibitorinhibit

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