HDAC8-IN-8

Cat. No.: HY-124782 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC₅₀ values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC₅₀ values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research.

For research use only. We do not sell to patients.

HDAC8-IN-8 Chemical Structure

CAS No. : 1884231-52-0

Size	Price	Stock	Quantity
1 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 785	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1170	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1525	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1970	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

hHDAC8

23.9 μM (IC₅₀)

smHDAC8

268.2 μM (IC₅₀)

hHDAC1

12.1 μM (IC₅₀)

hHDAC6

2.9 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BE(2)-C	IC₅₀	12.7 μM Compound: 20a	Cytotoxicity against human BE(2)-C cells assessed as reduction in cell viability by measuring metabolic activity after 72 hrs by WST-8 assay Cytotoxicity against human BE(2)-C cells assessed as reduction in cell viability by measuring metabolic activity after 72 hrs by WST-8 assay	[PMID: 29190092]

In Vitro

HDAC8-IN-8 (15a) (50 μM, 24 h) results in 69.1% viability of HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

273.28

Formula

C₁₅H₁₅NO₄

CAS No.

1884231-52-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C(OCC2=CC=CC=C2)=C1)OC)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (246 KB) HNMR (229 KB) RP-HPLC (129 KB) LCMS (175 KB)

Handling Instructions (2659 KB)

References

[1]. Heimburg T, et al. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem. 2016 Mar 24;59(6):2423-35. [Content Brief]

HDAC8-IN-8 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-81884231-52-0HDACHistone deacetylasesSchistosomiasis3-amidobenzohydroxamatesEnzyme inhibitory activityCytotoxicityHEK293 CellsCell viabilityInhibitorinhibitorinhibit

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