2. Anti-infection
  3. HBV
  4. HEC72702

HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers.

For research use only. We do not sell to patients.

HEC72702 Chemical Structure

HEC72702 Chemical Structure

CAS No. : 1793063-59-8

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HEC72702 Related Antibodies

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Description

HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers[1].

IC50 & Target

EC50: 0.039 µM (hepatitis B virus capsid)[1]
In Vivo

HEC72702 (50, 100 mg/kg; p.o.; daily for 7 days) dose-dependently reduces HBV DNA in both the plasma and livers copies[1].
Pharmacokinetic Parameters of HEC72702 in Male Sprague-Dawley rats[1].

dose (mg/kg) iv (2) po (5)
AUC(0-24 h) (h*ng/mL) 4110 4900
CL (mL/min/kg) 8.11
VSS (L/kg) 0.41
F % 47.7
Male Sprague-Dawley rats, 2 mg/kg iv; 5 mg/kg po[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-7 weeks, 16-18 g, Female BALB/c mice(HDI mouse model)[1]
Dosage: 50, 100 mg/kg
Administration: P.o.; daily for 7 days
Result: Demonstrated a dose-dependent reduction of HBV DNA in the plasma of infected mice.
Molecular Weight

581.45

Formula

C24H26BrFN4O5S
CAS No.
SMILES

O=C(O)CC[C@@H]1CN(CC2=C(C(OCC)=O)[C@H](C3=CC=C(F)C=C3Br)N=C(C4=NC=CS4)N2)CCO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HEC72702 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HEC727021793063-59-8HEC 72702HEC-72702HBVHepatitis B virusInhibitorinhibitorinhibit

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HEC72702
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HY-123767
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