2. Stem Cell/Wnt
  3. Hedgehog
  4. Hedgehog IN-5

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. Hedgehog IN-5 can be used for the research of fibrotic disease.

For research use only. We do not sell to patients.

Hedgehog IN-5 Chemical Structure

Hedgehog IN-5 Chemical Structure

CAS No. : 1544681-93-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Hedgehog IN-5 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. Hedgehog IN-5 can be used for the research of fibrotic disease[1].

In Vivo

Modeling methods: Bleomycin (HY-108345) (3 mg/kg; Intratracheal injection for 8 days)-induced pulmonary fibrosis model in rats. Hedgehog IN-5 (5-30 mg/kg; Oral administration after 8 days of moulding; once daily for 2 weeks) inhibits the progression of pulmonary fibrosis induced by Bleomycin (HY-108345) in several pathological evaluation indexes in SD rat model of unilateral pulmonary fibrosis, significantly[1].
Modeling methods: CCL4 (dissolved in olive oil at a dose of 0.5 μL/g; Oral administration; Three times a week for four weeks)-induced liver fibrosis model in C57BL/6 mice. Hedgehog IN-5 (5-20 mg/kg; Oral administration on the day of moulding; Once a day for 4 weeks) exhibits a certain trend of inhibiting CCl4-induced liver fibrosis. And primarily manifests as a reduction in hepatocyte degeneration and necrosis, as well as a decrease in fibrotic area in CCL4-induced liver fibrosis model in C57BL/6 mice[1].
Hedgehog IN-5 (10-20 mg/kg, 20mg/kg (Combined with BIBF1120 (50 mg/kg); Oral administration; Once a day for 20 days) alone or in combination with BIBF1120 significantly inhibits bleomycin-induced lung tissue inflammation and fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Unilateral pulmonary fibrosis in SD rat model[1]
Dosage: 5 mg/kg, 15 mg/kg, 30 mg/kg
Administration: Oral administration after 8 days of moulding; once daily for 2 weeks
Result: Reduced the scores of Bleomycin (HY-108345)-treated mice, significantly.
Collagen content in the lungs as well as myofibroblasts were quantified to assess the antifibrotic effect of Hedgehog IN-5, α-SMA protein percentage was significantly reduced with 30 mg/kg dose and collagen content was not significantly changed.
Animal Model: CCL4-induced liver fibrosis model in C57BL/6 mice[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Oral administration on the day of moulding; Once a day for four weeks
Result: Showed slow weight gain after one week and no significant weight gain after two weeks at the dose of 20 mg/kg.
Serum biochemical detection in peripheral blood showed that ALT and AST were significantly reduced but TBIL had no change at the dose of 20mg/kg.
Liver histopathological analysis showed that the liver injury score decreased and the fibrosis area of liver tissue decreased.
Molecular Weight

534.02

Formula

C27H31ClF3N5O
CAS No.
SMILES

FC(F)(C1=C(C(NC2=CC(C3=NC=C(C(C)C)N3)=C(C=C2)Cl)=O)C=CC(N4C[C@@H](N([C@@H](C4)C)C)C)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Hedgehog IN-5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hedgehog IN-51544681-93-7Hedgehog IN5Hedgehog IN 5Hedgehogfibrotic diseasesinflammationliver fibrosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Hedgehog IN-5
Cat. No.:
HY-153730
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.