Hepcidin-20 (human) 

Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains^[1][2][3].

2191.73

C₈₅H₁₃₅N₂₇O₂₃S₉

342790-23-2

Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bridge: Cys2-Cys8,Cys5-Cys18,Cys6-Cys17,Cys9-Cys14)

ICIFCCGCCHRSKCGMCCKT (Disulfide bridge: Cys2-Cys8,Cys5-Cys18,Cys6-Cys17,Cys9-Cys14)

O=C(N[C@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CO)=O)CCCNC(N)=N)[C@@H](NC([C@@](CSSC[C@](C(NCC(N[C@H]2CCSC)=O)=O)([H])NC1=O)([H])NC([C@](NC(CNC([C@@](CSSC[C@](C(N3)=O)([H])NC2=O)([H])NC([C@@](CSSC[C@H]3C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)([H])NC4=O)=O)=O)=O)([H])CSSC[C@@H](C(N[C@@](C(N[C@H]4CC5=CC=CC=C5)=O)([H])[C@@H](C)CC)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)CC6=CN=CN6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280(12):2842-54.  [Content Brief]

  [2]. Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57(9):4314-4321.  [Content Brief]

  [3]. Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30(4):435-46.  [Content Brief]