2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HER2-IN-20

HER2-IN-20 (compound 32) is a potent and selective HER2WT and HER2YVMA inhibitor with IC50 values of 49, 42 nM, respectively. HER2-IN-20 has the potential for the research of non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

HER2-IN-20 Chemical Structure

HER2-IN-20 Chemical Structure

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HER2-IN-20 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

HER2-IN-20 (compound 32) is a potent and selective HER2WT and HER2YVMA inhibitor with IC50 values of 49, 42 nM, respectively. HER2-IN-20 has the potential for the research of non-small cell lung cancer (NSCLC)[1].

IC50 & Target[1]

HER2(WT)

49 nM (IC50)

HER2 YVMA

42 nM (IC50)

EGFR (WT)

4584 nM (IC50)

Molecular Weight

572.03

Formula

C30H27ClFN7O2
SMILES

C=CC(N1[C@@]2([H])C[C@H](N3N=C(C4=CC(F)=C(OC5=CC=C6N(C)C=NC6=C5)C(Cl)=C4)C7=C(C)N=CN=C73)C[C@]1([H])CC2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HER2-IN-20 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-IN-20EGFREpidermal growth factor receptorErbB-1HER1HER2WTHER2YVMAEGFRWTNSCLCInhibitorinhibitorinhibit

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HER2-IN-20
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HY-163657
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