2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues E1/E2/E3 Enzyme
  4. HGC652

HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21.

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HGC652 Chemical Structure

HGC652 Chemical Structure

CAS No. : 3055558-98-7

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HGC652 Related Antibodies

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Description

HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1].

Molecular Weight

449.60

Formula

C23H28FNO3S2
CAS No.
SMILES

CN(C(C1=CC=C(C2=C(SC)C=C(F)C=C2)C=C1S(=O)(C)=O)=O)CC3CCCCC3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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HGC652 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HGC6523055558-98-7HGC 652HGC-652Molecular GluesE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseA549SK-N-ASU2OSA-431PANC-1MV-4-11KURAMOCHIMCF-7HCC1806MDA-MB-468NCI-H1373ternary complexInhibitorinhibitorinhibit

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