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  4. HI-236

HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLVIIB IC50p24 < 0.001 μM).

For research use only. We do not sell to patients.

HI-236 Chemical Structure

HI-236 Chemical Structure

CAS No. : 233271-65-3

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HI-236 Related Antibodies

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Description

HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLVIIB IC50p24 < 0.001 μM)[1].

IC50 & Target

wild type HTLVIIB IC50p24 <0.001 μM)[1]
Cellular Effect
Cell Line Type Value Description References
MT2 CC50
> 1 μM
Compound: HI-236
Cytotoxicity against human MT2 cells after 5 days by MTT assay
Cytotoxicity against human MT2 cells after 5 days by MTT assay
[PMID: 20605472]
MT2 EC50
0.042 μM
Compound: HI-236
Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as inhibition of viral-mediated cell death after 5 days by MTT assay
Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as inhibition of viral-mediated cell death after 5 days by MTT assay
[PMID: 20605472]
MT2 EC50
0.042 μM
Compound: HI-236
Antiviral activity against HIV1 3B in MT2 cells assessed as inhibition of viral-mediated T-cell death by MTT method
Antiviral activity against HIV1 3B in MT2 cells assessed as inhibition of viral-mediated T-cell death by MTT method
[PMID: 17317163]
MT2 EC50
0.048 μM
Compound: HI-236
Antiviral activity against nevirapine-resistant HIV1 3B infected in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay
Antiviral activity against nevirapine-resistant HIV1 3B infected in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay
[PMID: 18996020]
MT2 CC50
1 μM
Compound: HI-236
Cytotoxicity against mock-infected human MT2 cells after 5 days by MTT assay
Cytotoxicity against mock-infected human MT2 cells after 5 days by MTT assay
[PMID: 18996020]
MT2 EC50
1200 nM
Compound: HI-236
Antiviral activity against nevirapine-resistant HIV1 with reverse transcriptase Y181C mutation in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay
Antiviral activity against nevirapine-resistant HIV1 with reverse transcriptase Y181C mutation in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay
[PMID: 18996020]
MT2 CC50
18000 nM
Compound: HI-236
Cytotoxicity against HIV1 Y181C mutant infected human MT2 cells after 5 days by MTT assay
Cytotoxicity against HIV1 Y181C mutant infected human MT2 cells after 5 days by MTT assay
[PMID: 18996020]
Molecular Weight

396.30

Formula

C16H18BrN3O2S
CAS No.
SMILES

S=C(NC1=NC=C(C=C1)Br)NCCC2=CC(OC)=CC=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HI-236 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HI-236233271-65-3HI236HI 236HIVHuman immunodeficiency virusnon-nucleoside,HIVInhibitorinhibitorinhibit

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HI-236
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HY-121611
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