Himachalol 

Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.)^[1][2].

222.37

C₁₅H₂₆O

1891-45-8

C[C@@]1([C@@]2([H])[C@](C(C)(CCC1)C)([H])C=C(CC2)C)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shebaby W, et al. Himachalol induces apoptosis in B16-F10 murine melanoma cells and protects against skin carcinogenesis. J Ethnopharmacol. 2020 May 10;253:112545.  [Content Brief]

  [2]. Kar K, et al. Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol. J Pharm Sci. 1975 Feb;64(2):258-262.  [Content Brief]