HIV-1 integrase inhibitor 10 

HIV-1 integrase inhibitor 10 is an orally active HIV-1 allosteric integrase inhibitor (ALLINI). HIV-1 integrase inhibitor 10 can inhibit viral outgrowth of the NLRepRluc virus in MT-2 cells with EC₅₀ values of 3-5 nM. HIV-1 integrase inhibitor 10 can be used for the research of Human immunodeficiency virus-1 (HIV-1)^[1].

EC50 for NLRepRluc virus: 3.9 nM (T/T); 4.5 nM (N/A); 5.2 nM (A/A)^[1].

HIV-1 integrase inhibitor 10 (compound 11) has excellent antiviral potency for viruses containing the T/T, N/A and A/A polymorphs with EC₅₀ values of 3.9 nM, 4.5 nM and 5.2 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 integrase inhibitor 10 (compound 11) (1 mg/kg, iv. and 5 mg/kg, po., as solutions in 90:10 PEG-400:EtOH for IV dosing and 90:5:5 PEG-400:EtOH:TPGS for PO dosing) exhibits improved rat PK properties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

687.83

C₄₀H₄₅N₇O₄

CC1=NN2C(C(C3=CC=C4CN(CCC4=C3)C5=NC=NC6=C5OC7=C6C=CC=C7)=C(C([C@@H](C(O)=O)OC(C)(C)C)=C2C)N8CCC(C)(CC8)C)=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kyle Parcella, et al. Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors. Bioorg Med Chem. 2022 Aug 1;67:116833.  [Content Brief]