2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. HIV-1 integrase inhibitor 12

HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor for HIV-1 integrase with an IC50 of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC50 of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability (64%) and low clearance (0.16 L/hr/kg) in rats.

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HIV-1 integrase inhibitor 12 Chemical Structure

HIV-1 integrase inhibitor 12 Chemical Structure

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HIV-1 integrase inhibitor 12 Related Antibodies

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Description

HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor for HIV-1 integrase with an IC50 of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC50 of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability (64%) and low clearance (0.16 L/hr/kg) in rats[1].

Molecular Weight

469.66

Formula

C29H43NO4
SMILES

CC1=CC(C(NC2CCCCC2)=O)=C(C3=C1[C@@H](C(O)=O)OC(C)(C)C)CC[C@]43CC[C@H](C)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 integrase inhibitor 12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 integrase inhibitor 12HIV IntegraseMT-4HIV-1 NL4-3 WTInhibitorinhibitorinhibit

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