HIV-1 protease-IN-2 

HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC₅₀ of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants^[1].

IC₅₀: 2.53 nM (HIV-1 protease)^[1]

HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1^[1].
HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC₅₀s of 0.27 µM and 0.59 µM for HIV-1_NL4-3 and HIV^R_DRV^S, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

558.65

C₂₇H₃₄N₄O₇S

2248124-46-9

COC1=CC=C(C=C1)S(=O)(N(C[C@H]([C@@H](NC(CN2C=CC(NC2=O)=O)=O)CC3=CC=CC=C3)O)CC(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhu M, et al. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem. 2020 Jan 1;185:111866.  [Content Brief]