2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. HIV-IN-11

HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor.

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HIV-IN-11 Chemical Structure

HIV-IN-11 Chemical Structure

CAS No. : 160729-91-9

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HIV-IN-11 Related Antibodies

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Description

HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor[1].

Molecular Weight

653.81

Formula

C38H47N5O5
CAS No.
SMILES

O=C([C@@H](C[C@@H](CN1[C@@H](CN(CC1)CC2=CN=C3OC=CC3=C2)C(NC(C)(C)C)=O)O)CC4=CC=CC=C4)N[C@@H]5[C@@H](CC6=C5C=CC=C6)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-IN-11160729-91-9HIV ProteaseInhibitorinhibitorinhibit

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