2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. HL389-NHC2-PEG3-C2NH

HL389-NHC2-PEG3-C2NH inhibits proliferation of cancer cells MDA-MB-231 and MCF-7, with IC50 of 11.39 μM and 9.66 μM. HL389-NHC2-PEG3-C2NH can be utilized as a conjugate of an E3 ligase ligand and a linker, for the synthesis of PROTAC degrader HL435 (HY-161769).

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HL389-NHC2-PEG3-C2NH Chemical Structure

HL389-NHC2-PEG3-C2NH Chemical Structure

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HL389-NHC2-PEG3-C2NH Related Antibodies

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Description

HL389-NHC2-PEG3-C2NH inhibits proliferation of cancer cells MDA-MB-231 and MCF-7, with IC50 of 11.39 μM and 9.66 μM. HL389-NHC2-PEG3-C2NH can be utilized as a conjugate of an E3 ligase ligand and a linker, for the synthesis of PROTAC degrader HL435 (HY-161769)[1].

Molecular Weight

644.48

Formula

C28H33BrF3N3O6
SMILES

NCCCOCCOCCOCCCNC(COC1=C(/C=C(C(C=CC(C(F)(F)F)=C2)=C2N3)\C3=O)C=C(Br)C=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HL389-NHC2-PEG3-C2NH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HL389-NHC2-PEG3-C2NHE3 Ligase Ligand-Linker ConjugatesHCT116MCF-722RV1A549K562THP-1HelaHEK293TNOD-SCID mouseInhibitorinhibitorinhibit

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