HMBPP lithium (Synonyms: (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium)

Cat. No.: HY-134891 Purity: ≥95.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos.

For research use only. We do not sell to patients.

HMBPP lithium Chemical Structure

CAS No. : 396726-03-7

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1 mg	In-stock	Estimated Time of Arrival: December 31
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Description

In Vitro

HMBPP (10 μM) lithium stimulates the mosquito feeding behaviour in main mosquito vectors (HMBPP-supplemented red blood cells)^[2].
HMBPP (10 μM, 12 h) lithium activates human purified γδ T cell, and increases CD69, intracellular perforin, IFN-γ, and TNF-α production when γδ T cell are incubated with GBM cells (U251, U373 and primary GBM cultures)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HMBPP (50 mg/kg, i.m.) lithium plus IL-2 (s.c., 1 million unit, once daily for 5 days) induces pro-longed accumulation of Vγ2Vδ2 T effector cells in lungs of cynomolgus monkeys During inhalational Y.pestis infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Macaques infected with Y.pestis, 5 hours after inhalational Y.pestis infection, the macaques received HMBPP plus IL-2^[5]
Dosage:	50 mg/kg
Administration:	i.m., plus IL-2 (s.c., 1 million unit, once daily for 5 days)
Result:	Induced Vγ2Vδ2 T cell accumulation localized in pulmonary interstitials surrounding bloodvessels and airway mucosa in the lung tissues with no or mildplague lesions. Attenuated inhalation plague lesions in lungs.

Molecular Weight

279.89

Formula

C₅H₉Li₃O₈P₂

CAS No.

396726-03-7

Appearance

Solid

Color

White to off-white

SMILES

O=P(OP(O[Li])(O[Li])=O)(O[Li])OC/C=C(C)/CO

Structure Classification

Others

Initial Source

Microorganisms

Escherichia coli

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: ≥95.0%

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Data Sheet (271 KB) SDS (392 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Hintz M, et al., Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509(2):317-22. [Content Brief]

[2]. Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4(1):1161. [Content Brief]

[3]. Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153(3):403-415. [Content Brief]

[4]. Nguyen K,et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31(11):4697-4706. [Content Brief]

[5]. Huang D, et al. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7553-8. [Content Brief]

HMBPP lithium Related Classifications

Inflammation/Immunology Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HMBPP396726-03-7(E)-4-Hydroxy-3-methyl-but-2-enyl diphosphateNuclear Factor of activated T Cells (NFAT)MosquitophagostimulantAnopheles coluzziiAn. arabiensisAn. gambiae s.s.Aedes aegyptiCulex pipiensCulex torrentiumInhibitorinhibitorinhibit

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HMBPP lithium (Synonyms: (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium)

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