HO-PEG10-CH2COOH

Cat. No.: HY-133304 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

HO-PEG10-CH2COOH Chemical Structure

CAS No. : 2250056-53-0

Size	Price	Stock	Quantity
50 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
1 g	USD 450	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.58

Formula

C₂₂H₄₄O₁₃

CAS No.

2250056-53-0

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (193.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9358 mL	9.6790 mL	19.3581 mL
5 mM	0.3872 mL	1.9358 mL	3.8716 mL
10 mM	0.1936 mL	0.9679 mL	1.9358 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (238 KB) HNMR (266 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9358 mL	9.6790 mL	19.3581 mL	48.3952 mL
	5 mM	0.3872 mL	1.9358 mL	3.8716 mL	9.6790 mL
	10 mM	0.1936 mL	0.9679 mL	1.9358 mL	4.8395 mL
	15 mM	0.1291 mL	0.6453 mL	1.2905 mL	3.2263 mL
	20 mM	0.0968 mL	0.4840 mL	0.9679 mL	2.4198 mL
	25 mM	0.0774 mL	0.3872 mL	0.7743 mL	1.9358 mL
	30 mM	0.0645 mL	0.3226 mL	0.6453 mL	1.6132 mL
	40 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2099 mL
	50 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.9679 mL
	60 mM	0.0323 mL	0.1613 mL	0.3226 mL	0.8066 mL
	80 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6049 mL
	100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.4840 mL

HO-PEG10-CH2COOH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HO-PEG10-CH2COOH2250056-53-0PROTAC LinkersInhibitorinhibitorinhibit

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