2. PROTAC
  3. PROTAC Linkers
  4. HO-PEG11-OH

HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

HO-PEG11-OH Chemical Structure

HO-PEG11-OH Chemical Structure

CAS No. : 6809-70-7

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Based on 1 publication(s) in Google Scholar

HO-PEG11-OH Related Antibodies

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Description

HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HO-PEG11-OH Related Antibodies
Molecular Weight

502.59

Formula

C22H46O12
CAS No.
Appearance

Liquid (Density: 1.116±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (198.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9897 mL 9.9485 mL 19.8969 mL
5 mM 0.3979 mL 1.9897 mL 3.9794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (237 KB) HNMR (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9897 mL 9.9485 mL 19.8969 mL 49.7423 mL
5 mM 0.3979 mL 1.9897 mL 3.9794 mL 9.9485 mL
10 mM 0.1990 mL 0.9948 mL 1.9897 mL 4.9742 mL
15 mM 0.1326 mL 0.6632 mL 1.3265 mL 3.3162 mL
20 mM 0.0995 mL 0.4974 mL 0.9948 mL 2.4871 mL
25 mM 0.0796 mL 0.3979 mL 0.7959 mL 1.9897 mL
30 mM 0.0663 mL 0.3316 mL 0.6632 mL 1.6581 mL
40 mM 0.0497 mL 0.2487 mL 0.4974 mL 1.2436 mL
50 mM 0.0398 mL 0.1990 mL 0.3979 mL 0.9948 mL
60 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8290 mL
80 mM 0.0249 mL 0.1244 mL 0.2487 mL 0.6218 mL
100 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4974 mL
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HO-PEG11-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HO-PEG11-OH6809-70-7PROTAC LinkersInhibitorinhibitorinhibit

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