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hosu-53

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125535
    OSU-53

    		AMPK mTOR Autophagy Atg8/LC3 Cancer
    OSU-53 is an orally active AMPK activator (EC50: 0.3 μM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1α and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer .
    OSU-53

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