2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. HP1142

HP1142 is a potent and selective inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1142 is a benzoimidazole scaffold-based compound. HP1142 has the potential for the research of FLT3/ITD leukemia.

For research use only. We do not sell to patients.

HP1142 Chemical Structure

HP1142 Chemical Structure

CAS No. : 381173-58-6

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HP1142 Related Antibodies

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Description

HP1142 is a potent and selective inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1142 is a benzoimidazole scaffold-based compound. HP1142 has the potential for the research of FLT3/ITD leukemia[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
> 0.4 μM
Compound: HP1142
Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
HL-60 IC50
> 50 μM
Compound: HP1142
Antiproliferative activity against human HL-60 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human HL-60 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
MOLM-13 IC50
113.4 nM
Compound: HP1142
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
MV4-11 IC50
189 nM
Compound: HP1142
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs ny MTS assay
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs ny MTS assay
[PMID: 35148084]
Molecular Weight

359.42

Formula

C22H21N3O2
CAS No.
SMILES

COC(C(OC)=C1)=CC=C1CNC2=CC3=C(C=C2)N(C4=CC=CC=C4)C=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HP1142 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HP1142381173-58-6HP 1142HP-1142FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3tyrosine kinasebenzoimidazolescaffold-basedleukemiaInhibitorinhibitorinhibit

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HY-145691
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