2. Protein Tyrosine Kinase/RTK Anti-infection
  3. ROS Kinase Bacterial
  4. HS-291

HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb.

For research use only. We do not sell to patients.

HS-291 Chemical Structure

HS-291 Chemical Structure

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HS-291 Related Antibodies

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Description

HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1].

In Vitro

HS-291 (0.1-10 μM, 24 h) inhibits Bb culture viability when excited with nrIR (Ex: 693nm 5 J/cm2)[1].
HS-291 (10 μM, 90 min) can specifically target Bb in Bb culture[1].
HS-291 (0-10 μM, 24 h) causes cell wall blebbing, nucleoid condensation and loss of cell wall integrity of cells when excited with nrIR (Ex: 693nm 5 J/cm2)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HS-291 Related Antibodies
Molecular Weight

2961.44

Formula

C156H194N18O36S2
SMILES

O=C(CCC1=C(N2)/C=C3C(CCC(OC)=O)=C(C)C(/C=C4N/C(C(C)=C\4C=C)=C\C(C5=CC=C([C@H]([C@]5/6C)C(OC)=O)C(OC)=O)=NC6=C/C2=C1C)=N/3)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC7=CC=C(N8C(NN=C8C9=C(O)C=C(O)C(C(C)C)=C9)=S)C=C7)=O.CC(CCC%10=C%11NC(/C=C(N=C(/C=C(N/C%12=C\C(C(C)=C/%13CCC(ONCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC(C=C%14)=CC=C%14N%15C(C(C=C(C(O)=C%16)C(C)C)=C%16O)=NNC%15=S)=O)=O)=NC%13=C/%11)/C(C)=C%12C=C)C%17=CC=C(C(OC)=O)[C@H]%18C(OC)=O)/[C@@]%17%18C)=C%10C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HS-291 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-291HS291HS 291ROS KinaseBacterialHtpGBorrelia burgdorferi ( Bb)AntibioticInhibitorinhibitorinhibit

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