2. Anti-infection
  3. Bacterial
  4. HSGN-94

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.

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HSGN-94 Chemical Structure

HSGN-94 Chemical Structure

CAS No. : 2570797-85-0

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HSGN-94 Related Antibodies

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Description

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model[1].

In Vitro

HSGN-94 (50 μM; 30 min) directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA)[1].
HSGN-94 (0.25 μg/mL; 2 h) downregulates the expression level of PgsA, an essential protein for phospholipid synthesis in the bacteria S. aureus[1].
HSGN-94 (16, 32, 64, and 128 μg/mL; 2 h) is not toxic to HaCat cells at concentrations up to 64 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSGN-94 Related Antibodies
In Vivo

HSGN-94 (2%; external use; twice daily for 5 days) decreases MRSA USA300 in infected wounds of mice and results resolution of inflammation in infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA murine wound infection model[1]
Dosage: 2%
Administration: External use; twice daily for 5 days
Result: Reduced the levels of the pro-inflammatory cytokines, monocyte chemo attractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) in MRSA USA300 skin lesions.
Molecular Weight

508.51

Formula

C23H23F3N4O4S
CAS No.
SMILES

O=S(C1=CC=C(C=C1)C(NC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)=O)(N4C[C@@H](C[C@@H](C4)C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSGN-94 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSGN-942570797-85-0HSGN94HSGN 94BacterialInhibitorinhibitorinhibit

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