2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. HSP Na+/K+ ATPase
  4. Hsp90-IN-38

Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong HSP90 binding affinity with a Kd of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC50 of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC50s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively.

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Hsp90-IN-38 Chemical Structure

Hsp90-IN-38 Chemical Structure

CAS No. : 3065556-04-6

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Hsp90-IN-38 Related Antibodies

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Description

Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong HSP90 binding affinity with a Kd of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC50 of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC50s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively[1].

IC50 & Target[1]

HSP90

68 nM (Kd)

Molecular Weight

493.59

Formula

C28H35N3O5
CAS No.
SMILES

O=C([C@@H]1N(C(C2=CC(C3CC3)=C(O)C=C2O)=O)C[C@@H](C4=CC=CC=C4)C1)NCCCN5CCOCC5
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Purity & Documentation
References
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Hsp90-IN-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-383065556-04-6HSPNa+/K+ ATPaseHeat shock proteinsSodium potassium pumpHSP90 inhibitorsantitumorpharmacokinetic parametersHSP90α selectivityInhibitorinhibitorinhibit

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